Micky van de Ven Double Halts Everton's Run at New Stadium
The Dutch defender emerged as the initial backline player to net twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net two times in first half
The home side's defender has goal ruled after VAR review
Pape Matar Sarr scores third in dying moments
This loss is the Merseyside club's first at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run in away games in the top division and handed Everton their initial loss at Hill Dickinson Stadium.
Everton were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman struck twice from corners in the opening 45 minutes to put their impressive record at risk, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker Richarlison - headed home a final goal to seal the victory.
The Everton defender thought he had levelled the tally a short while after the defender's opener, glancing a bullet header past the Spurs keeper from an set-piece.
Beto, meanwhile, missed a handful of chances, while the Italian goalkeeper made a succession of fine stops to ensure Tottenham went five away games unbeaten in the Premier League.
But the video assistant referee stepped in, advising Craig Pawson to check the score on the pitchside monitor and the official ruled that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side up to third in the division, a handful of points off north London rivals and leaders the Gunners.
The Merseyside club remain 14th and are six points clear of the relegation zone.
Spurs breakdown: Van de Ven excels in duties at both ends of pitch
After a uninspiring midweek performance in the European competition against Monaco, where they managed a only two shots on goal, Frank opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder heading the ball toward the face of goal for an unmarked Van de Ven to score.
And the captain - filling in as skipper in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he rose above the England keeper to head home.
Van de Ven was equally impressive in defensive duties, partnering well with his defensive colleague as the duo handled excellently with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees missing finishing touch
Everton's new home had been a fortress, but it seems the freshness may have worn off somewhat and fans flocked to the exits after the midfielder's final goal for Tottenham.
The break in Everton's unbeaten home run will not be a massive worry for David Moyes, but their striker situation will be.
The forward and Thierno Barry - the Everton's two recognised centre-forwards - had netted just one league goal between them before the weekend's outing.
And they were failed to add to that poor record on a wet and gloomy evening on in Liverpool.
The striker's performance was epitomized when he opted to overhead kick a golden opportunity from close range, even with having space and time to reposition for a simpler attempt that would have challenged the keeper.
The substitute, too, was unable to influence the game after replacing the starter in the 65th minute.
It wasn't for a shortage of chance. Most of Everton's offensive moves came through the winger and Ndiaye, who tirelessly delivered dangerous balls into the Spurs box.
Upcoming fixtures for these two sides?
Everton: The team travel to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club travel to St James' Park on late October for their fourth-round Carabao Cup match against the Magpies.